Prostate carcinoma is one of the most common (leading) tumors in men. Often it is diagnosed at an early stage. The present study shows that in mice NADPH oxidase expression (that is that genes encoding this enzyme are particularly active) is associated with progressive prostate carcinoma.
It is possible to inhale NADPH oxidase from graviola pulp extract. Graviola contains acetogenin which has a strong anticancer effect. Acetogenin inhibits the activity of NADPH oxidase in prostate carcinoma cells. Expression of NADPH oxidase components is also reduced.

Graviola also has been shown to inhibit the proliferation (growth and reproduction) of prostate carcinoma cells. It is important to note that Graviola extract did not inhibit the NADPH oxidase activity of healthy cells. Graviola also did not inhibit the growth of healthy cells.
Graviola extract and the ingredient acetogenine could thus be an important means for the treatment and prevention of prostate cancer (carcinoma).
Acetogenins inhibit the complex 1 of the respiratory chain in the mitochondria. Tumor cells have a more extensive ATP requirement than healthy cells and are therefore very susceptible to this inhibition. Elevated NADPH oxidase activity was also detected in pancreatic carcinoma and breast tumor.

Gagan Deep, Rahul Kumar, Anil K. Jain, Deepanshi Dhar, Gati K. Panigrahi, Anowar Hussain, Chapla Agarwal, Tamam El-Elimat, Vincent P. Sica, Nicholas H. Oberlies & Rajesh Agarwal

Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity
Scientific Reports 6, March 2016